DoxyPEP for STI Prevention Doxycycline post-exposure prophylaxis
- May help reduce the risk of syphilis, chlamydia, and gonorrhea
- Taken within 72 hours after condomless sex
- Simple, on-demand oral dose, only when you need it
- Supported by clinical studies and CDC guidance
Take within 72 hours
One dose after condomless sex, as prescribed
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DoxyPEP is a post-exposure prophylaxis (PEP) regimen using doxycycline, used to help reduce the risk of bacterial sexually transmitted infections (STIs) such as syphilis, chlamydia, and gonorrhea.
Taken within 72 hours after condomless sex, DoxyPEP may help lower the chance of these infections taking hold, in a similar way to how emergency contraception helps reduce the chance of pregnancy after sex.
DoxyPEP does not protect against HIV or other STIs and is not a substitute for condoms or regular STI testing. Doxycycline is FDA-approved as an antibiotic; its use as DoxyPEP is off-label and prescribed at the discretion of a licensed clinician.
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Who Is DoxyPEP Best Suited For?
A licensed clinician will confirm suitability during your online consultation, but DoxyPEP may be a good fit for the following:
- Are a gay, bisexual, or other man who has sex with men, or a transgender woman, and have had syphilis, chlamydia, or gonorrhea in the past 12 months
- Have condomless sex and want an extra layer of protection against some bacterial STIs
- Prefer an on-demand option taken only after sex, rather than a daily medication
- Keep up with regular STI testing, typically every 3 to 6 months
- Have no known allergy to doxycycline or other tetracycline antibiotics
- Are not pregnant
This information is general and does not replace a clinical consultation. Final suitability is determined by a licensed prescriber based on your full medical and sexual health history. DoxyPEP does not protect against HIV and is not a substitute for condoms or regular testing.
More Info About DoxyPEP Doxycycline post-exposure prophylaxis
DoxyPEP (doxycycline post-exposure prophylaxis) is a clinician-guided prevention approach that may reduce the likelihood of certain bacterial STIs after higher-risk sexual exposure, when appropriate for you. It does not prevent HIV and does not replace condoms, routine testing, or other prevention strategies.
When prescribed and used as directed, DoxyPEP may reduce the chance of some bacterial STIs, such as syphilis and chlamydia, and to a lesser extent gonorrhea. Effectiveness can vary by person and local resistance patterns. Your clinician will review whether it's appropriate for you.
No. Doxycycline is an antibiotic and does not prevent HIV. If you want HIV prevention options, ask your clinician about PrEP, PEP, and testing schedules that fit your needs.
Eligibility is individualized. Your clinician will consider your sexual health history, recent STI testing, medications, allergies, and potential benefits and risks. DoxyPEP is not suitable for everyone.
Your clinician will prescribe the appropriate dose and instructions for you. If doxycycline 100mg capsules are supplied, follow your plan exactly as provided in your clinical instructions.
DoxyPEP is typically taken as soon as possible, within 72 hours after condomless sex. Follow your clinician's guidance on timing. If you're unsure what to do, message your care team before taking any medication.
Yes. DoxyPEP is not a complete prevention solution. Condoms, routine STI screening, symptom awareness, and HIV prevention options remain important.
Common side effects can include nausea, upset stomach, heartburn, and sensitivity to sunlight. Rare but serious reactions can occur. Stop and seek urgent care if you have signs of a severe allergic reaction, such as swelling, trouble breathing, or hives.
Many people tolerate doxycycline better when taking it with a full glass of water and staying upright afterward. Follow your clinician's instructions about taking it with food, and don't take it right before lying down.
Some products, especially those containing calcium, magnesium, aluminum, iron, or zinc, can interfere with absorption. Your clinician will advise how to separate doses if needed.
Antibiotic resistance is a real consideration. That's why DoxyPEP should only be used under clinician guidance, with appropriate eligibility screening and follow-up.
If you develop symptoms such as discharge, sores, rash, burning when urinating, or pelvic or testicular pain, get tested and evaluated promptly. Do not rely on DoxyPEP to treat symptoms.
Testing frequency depends on your risk profile and local guidance. Many people benefit from routine screening on a regular schedule. Your clinician will recommend an interval that fits your situation.
Some people use both, but it must be clinician-guided to make sure it's appropriate and safe for your medical history and medications. Tell your clinician about all prescriptions and supplements you use.
Doxycycline may not be appropriate if you have a known allergy to tetracyclines, certain medical conditions, or are pregnant or breastfeeding. Your clinician will screen for these during your online visit.
No. DoxyPEP is taken after certain exposures, not as a daily antibiotic. Your clinician will explain the plan recommended for you.
Share your recent STI testing history, any symptoms, allergies, current medications (including acne treatments and supplements), and any medical conditions. Accurate information helps ensure safe prescribing.
You complete a secure online assessment. A licensed clinician reviews your information and determines eligibility. If appropriate, a prescription may be issued and fulfilled according to applicable regulations.
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Start your online visit to see if DoxyPEP is right for you. If you have urgent symptoms or concerns, seek in-person care promptly.